PGRx : Central demyelination FRESH-PEF2383-en Elodie AUBRUN PGRx : Central demyelination FRESH-PEF2383-en 2383 FRESH-PEF2383 Lamiae GRIMALDI-BENSOUDA L.A. SANTE EPIDEMIOLOGIE EVALUATION RECH Epidemiology France Portal (PEF) L.A. SANTE EPIDEMIOLOGIE EVALUATION RECH null Lamiae;GRIMALDI-BENSOUDA pharmaco-epidemiology Paediatrics Neurology Multiple sclerosis Surveillance and assessment of the risk of central demyelination associated with drug or vaccine use in real life situations.null null France Individuals General population Male Female Infant, Newborn (birth to 28 days) Infant (28 days to 2 years) Child, Preschool (2 to 5 years) Child (6 to 12 years) Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) Aged (65 to 79 years) For the cases: patients, males and females aged from 0 to 79 years, having a first central demyelinating event reported by the neurologist, for which the first symptoms of the episode occurred less than 12 months ago. For the controls: patients, males and females aged from 0 to 79 years, having consulted a general practitioner. Clinical dataParticipant-reported health data Health event/morbidity Other [10000-20000[ individuals Converting or copying information into a structured record Interview with the participant (including clinical) Observational Study Observational Study Case-control study 517 cas et 11125 référents Unknown To be defined Access on specific project only